Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation

BACKGROUND: The complex of Dock180/ELMO1 that functions as a bipartite guanine nucleotide exchange factor for Rac is essential for diverse physiological and pathological processes of cells such as cell migration, phagocytosis, and invasion of cancer cells. Among the Src-family tyrosine kinases (SFKs...

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Veröffentlicht in:Cell Commun Signal
Hauptverfasser: Makino, Yoshinori, Tsuda, Masumi, Ohba, Yusuke, Nishihara, Hiroshi, Sawa, Hirofumi, Nagashima, Kazuo, Tanaka, Shinya
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513707/
https://ncbi.nlm.nih.gov/pubmed/26205662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-015-0113-y
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