NRAS(Q61R), BRAF(V600E) immunohistochemistry: a concomitant tool for mutation screening in melanomas

BACKGROUND: The determination of NRAS and BRAF mutation status is a major requirement in the treatment of patients with metastatic melanoma. Mutation specific antibodies against NRAS(Q61R) and BRAF(V600E) proteins could offer additional data on tumor heterogeneity. The specificity and sensitivity of...

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Bibliografiske detaljer
Udgivet i:Diagn Pathol
Main Authors: Uguen, Arnaud, Talagas, Matthieu, Costa, Sebastian, Samaison, Laura, Paule, Laure, Alavi, Zarrin, De Braekeleer, Marc, Le Marechal, Cédric, Marcorelles, Pascale
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513673/
https://ncbi.nlm.nih.gov/pubmed/26204954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13000-015-0359-0
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