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Tryptophan Scanning Mutagenesis Identifies the Molecular Determinants of Distinct Barttin Functions

CLC-K chloride channels are expressed in the kidney and in the inner ear and require the accessory subunit barttin for proper function and membrane insertion. Barttin exerts multiple functions on CLC-proteins: it modifies protein stability and intracellular trafficking as well as channel activity, i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Wojciechowski, Daniel, Fischer, Martin, Fahlke, Christoph
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513129/
https://ncbi.nlm.nih.gov/pubmed/26063802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625376
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