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Tryptophan Scanning Mutagenesis Identifies the Molecular Determinants of Distinct Barttin Functions
CLC-K chloride channels are expressed in the kidney and in the inner ear and require the accessory subunit barttin for proper function and membrane insertion. Barttin exerts multiple functions on CLC-proteins: it modifies protein stability and intracellular trafficking as well as channel activity, i...
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| Publicado en: | J Biol Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4513129/ https://ncbi.nlm.nih.gov/pubmed/26063802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625376 |
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