The Levels of a Universally Conserved tRNA Modification Regulate Cell Growth

N(6)-Threonylcarbamoyl-adenosine (t(6)A) is a universal modification occurring at position 37 in nearly all tRNAs that decode A-starting codons, including the eukaryotic initiator tRNA (tRNA(i)(Met)). Yeast lacking central components of the t(6)A synthesis machinery, such as Tcs3p (Kae1p) or Tcs5p (...

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Udgivet i:J Biol Chem
Main Authors: Rojas-Benitez, Diego, Thiaville, Patrick C., de Crécy-Lagard, Valérie, Glavic, Alvaro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513126/
https://ncbi.nlm.nih.gov/pubmed/26063805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665406
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