Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum

In mammalian cells, signal peptide-dependent protein transport into the endoplasmic reticulum (ER) is mediated by a dynamic polypeptide-conducting channel, the heterotrimeric Sec61 complex. Previous work has characterized the Sec61 complex as a potential ER Ca(2+) leak channel in HeLa cells and iden...

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Vydáno v:J Biol Chem
Hlavní autoři: Schorr, Stefan, Klein, Marie-Christine, Gamayun, Igor, Melnyk, Armin, Jung, Martin, Schäuble, Nico, Wang, Qian, Hemmis, Birgit, Bochen, Florian, Greiner, Markus, Lampel, Pavel, Urban, Sabine Katharina, Hassdenteufel, Sarah, Dudek, Johanna, Chen, Xing-Zhen, Wagner, Richard, Cavalié, Adolfo, Zimmermann, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513120/
https://ncbi.nlm.nih.gov/pubmed/26085089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.636639
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