NEU1 Sialidase Regulates Membrane-tethered Mucin (MUC1) Ectodomain Adhesiveness for Pseudomonas aeruginosa and Decoy Receptor Release

Airway epithelia express sialylated receptors that recognize exogenous danger signals. Regulation of receptor responsiveness to these signals remains incompletely defined. Here, we explore the mechanisms through which the human sialidase, neuraminidase-1 (NEU1), promotes the interaction between the...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Lillehoj, Erik P., Hyun, Sang Won, Liu, Anguo, Guang, Wei, Verceles, Avelino C., Luzina, Irina G., Atamas, Sergei P., Kim, K. Chul, Goldblum, Simeon E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513093/
https://ncbi.nlm.nih.gov/pubmed/25963144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.657114
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