The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo

Neuraminidase-1 (NEU1) is the predominant sialidase expressed in human airway epithelia and lung microvascular endothelia where it mediates multiple biological processes. We tested whether the NEU1-selective sialidase inhibitor, C9-butyl-amide-2-deoxy-2,3-dehydro-N-acetylneuraminic acid (C9-BA-DANA)...

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Detalhes bibliográficos
Publicado no:Glycobiology
Main Authors: Hyun, Sang W, Liu, Anguo, Liu, Zhenguo, Cross, Alan S, Verceles, Avelino C, Magesh, Sadagopan, Kommagalla, Yadagiri, Kona, Chandrababunaidu, Ando, Hiromune, Luzina, Irina G, Atamas, Sergei P, Piepenbrink, Kurt H, Sundberg, Eric J, Guang, Wei, Ishida, Hideharu, Lillehoj, Erik P, Goldblum, Simeon E
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Original articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884327/
https://ncbi.nlm.nih.gov/pubmed/27226251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cww060
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