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Neuraminidase 1–mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection

Pseudomonas aeruginosa (Pa) expresses an adhesin, flagellin, that engages the mucin 1 (MUC1) ectodomain (ED) expressed on airway epithelia, increasing association of MUC1-ED with neuraminidase 1 (NEU1) and MUC1-ED desialylation. The MUC1-ED desialylation unmasks both cryptic binding sites for Pa and...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Lillehoj, Erik P., Guang, Wei, Hyun, Sang W., Liu, Anguo, Hegerle, Nicolas, Simon, Raphael, Cross, Alan S., Ishida, Hideharu, Luzina, Irina G., Atamas, Sergei P., Goldblum, Simeon E.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333888/
https://ncbi.nlm.nih.gov/pubmed/30429216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006022
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