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Statistical controversies in clinical research: scientific and ethical problems with adaptive randomization in comparative clinical trials
BACKGROUND: In recent years, various outcome adaptive randomization (AR) methods have been used to conduct comparative clinical trials. Rather than randomizing patients equally between treatments, outcome AR uses the accumulating data to unbalance the randomization probabilities in favor of the trea...
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| Publié dans: | Ann Oncol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4511222/ https://ncbi.nlm.nih.gov/pubmed/25979922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdv238 |
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