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An mTORC1-Mdm2-Drosha Axis for miRNA Biogenesis in Response to Glucose- and Nutrient-deprivation
mTOR senses nutrient and energy status to regulate cell survival and metabolism in response to environmental changes. Surprisingly, targeted mutation of Tsc1, a negative regulator of mTORC1, caused a broad reduction in miRNAs due to Drosha degradation. Conversely, targeted mutation of Raptor, an ess...
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| 出版年: | Mol Cell |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4511160/ https://ncbi.nlm.nih.gov/pubmed/25639470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.034 |
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