Gaucher Disease-Induced Pluripotent Stem Cells Display Decreased Erythroid Potential and Aberrant Myelopoiesis

Gaucher disease (GD) is the most common lysosomal storage disease resulting from mutations in the lysosomal enzyme glucocerebrosidase (GCase). The hematopoietic abnormalities in GD include the presence of characteristic Gaucher macrophages that infiltrate patient tissues and cytopenias. At present,...

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Detalhes bibliográficos
Publicado no:Stem Cells Transl Med
Main Authors: Sgambato, Judi A., Park, Tea Soon, Miller, Diana, Panicker, Leelamma M., Sidransky, Ellen, Lun, Yu, Awad, Ola, Bentzen, Søren M., Zambidis, Elias T., Feldman, Ricardo A.
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2015
Assuntos:
Pluripotent Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511143/
https://ncbi.nlm.nih.gov/pubmed/26062980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2014-0213
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