DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas

BACKGROUND: Lynch syndrome (LS) is associated with germline mutations in DNA mismatch repair (MMR) genes. The first “hit” to inactivate one allele of the predisposing MMR gene is present in every cell, contributing to accelerated tumorigenesis. Less information is available of the nature, timing, an...

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Veröffentlicht in:Clin Epigenetics
Hauptverfasser: Valo, Satu, Kaur, Sippy, Ristimäki, Ari, Renkonen-Sinisalo, Laura, Järvinen, Heikki, Mecklin, Jukka-Pekka, Nyström, Minna, Peltomäki, Päivi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511034/
https://ncbi.nlm.nih.gov/pubmed/26203307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0102-4
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