DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas

BACKGROUND: Lynch syndrome (LS) is associated with germline mutations in DNA mismatch repair (MMR) genes. The first “hit” to inactivate one allele of the predisposing MMR gene is present in every cell, contributing to accelerated tumorigenesis. Less information is available of the nature, timing, an...

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Bibliografiska uppgifter
I publikationen:Clin Epigenetics
Huvudupphovsmän: Valo, Satu, Kaur, Sippy, Ristimäki, Ari, Renkonen-Sinisalo, Laura, Järvinen, Heikki, Mecklin, Jukka-Pekka, Nyström, Minna, Peltomäki, Päivi
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2015
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511034/
https://ncbi.nlm.nih.gov/pubmed/26203307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0102-4
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