DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression

BACKGROUND: DNA mismatch repair (MMR) defects are a major factor in colorectal tumorigenesis in Lynch syndrome (LS) and 15% of sporadic cases. Some adenomas from carriers of inherited MMR gene mutations have intact MMR protein expression implying other mechanisms accelerating tumorigenesis. We deter...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Mäki-Nevala, Satu, Valo, Satu, Ristimäki, Ari, Sarhadi, Virinder, Knuutila, Sakari, Nyström, Minna, Renkonen-Sinisalo, Laura, Lepistö, Anna, Mecklin, Jukka-Pekka, Peltomäki, Päivi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355728/
https://ncbi.nlm.nih.gov/pubmed/30578081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.018
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