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Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations
Phosphofructokinase-1 (PFK1), the “gatekeeper” of glycolysis, catalyses the committed step of the glycolytic pathway by converting fructose 6-phosphate (F6P) to fructose 1,6-bisphosphate. Allosteric activation and inhibition of PFK1 by over 10 metabolites and in response to hormonal signaling fine-t...
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| Published in: | Nature |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4510984/ https://ncbi.nlm.nih.gov/pubmed/25985179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14405 |
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