The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis

Although Notch1 and Notch2 are closely related paralogs and function through the same canonical signaling pathway, they contribute to different outcomes in some cell and disease contexts. To understand the basis for these differences, we examined in detail mice in which the Notch intracellular domai...

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Detalles Bibliográficos
Publicado en:Development
Main Authors: Liu, Zhenyi, Brunskill, Eric, Varnum-Finney, Barbara, Zhang, Chi, Zhang, Andrew, Jay, Patrick Y., Bernstein, Irv, Morimoto, Mitsuru, Kopan, Raphael
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510869/
https://ncbi.nlm.nih.gov/pubmed/26062937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.125492
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