A common Shox2–Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node

In humans, atrial fibrillation is often triggered by ectopic pacemaking activity in the myocardium sleeves of the pulmonary vein (PV) and systemic venous return. The genetic programs that abnormally reinforce pacemaker properties at these sites and how this relates to normal sinoatrial node (SAN) de...

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Publicado en:Development
Autores principales: Ye, Wenduo, Wang, Jun, Song, Yingnan, Yu, Diankun, Sun, Cheng, Liu, Chao, Chen, Fading, Zhang, Yanding, Wang, Fen, Harvey, Richard P., Schrader, Laura, Martin, James F., Chen, YiPing
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510860/
https://ncbi.nlm.nih.gov/pubmed/26138475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.120220
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