Functional Redundancy between Human SHOX and Mouse Shox2 Genes in the Regulation of Sinoatrial Node Formation and Pacemaking Function

The homeodomain transcription factor Shox2 plays a crucial regulatory role in the development of sinoatrial node (SAN) by repressing the expression of Nkx2.5, as demonstrated by failed differentiation of SAN in Shox2 null mice. The SHOX (short stature homeobox) gene family consists of two closely re...

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Bibliografske podrobnosti
Main Authors: Liu, Hongbing, Chen, Chao-Hui, Espinoza-Lewis, Ramón A., Jiao, Zhen, Sheu, Ivana, Hu, Xuefeng, Lin, Minkui, Zhang, Yanding, Chen, YiPing
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Developmental Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089547/
https://ncbi.nlm.nih.gov/pubmed/21454626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234252
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