Functional Redundancy between Human SHOX and Mouse Shox2 Genes in the Regulation of Sinoatrial Node Formation and Pacemaking Function

The homeodomain transcription factor Shox2 plays a crucial regulatory role in the development of sinoatrial node (SAN) by repressing the expression of Nkx2.5, as demonstrated by failed differentiation of SAN in Shox2 null mice. The SHOX (short stature homeobox) gene family consists of two closely re...

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Main Authors: Liu, Hongbing, Chen, Chao-Hui, Espinoza-Lewis, Ramón A., Jiao, Zhen, Sheu, Ivana, Hu, Xuefeng, Lin, Minkui, Zhang, Yanding, Chen, YiPing
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089547/
https://ncbi.nlm.nih.gov/pubmed/21454626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234252
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