KRAS-dependent sorting of miRNA to exosomes

Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. To test whether exosomal RNAs also contribute to changes in gene expression in recipient cells, and whether mutant KRAS might regulate the composition of secreted microRNAs (miRNAs), w...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Cha, Diana J, Franklin, Jeffrey L, Dou, Yongchao, Liu, Qi, Higginbotham, James N, Demory Beckler, Michelle, Weaver, Alissa M, Vickers, Kasey, Prasad, Nirpesh, Levy, Shawn, Zhang, Bing, Coffey, Robert J, Patton, James G
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Human Biology and Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510696/
https://ncbi.nlm.nih.gov/pubmed/26132860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07197
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