Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

Activating mutations in KRAS occur in 30% to 40% of colorectal cancers. How mutant KRAS alters cancer cell behavior has been studied intensively, but non-cell autonomous effects of mutant KRAS are less understood. We recently reported that exosomes isolated from mutant KRAS-expressing colon cancer c...

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Main Authors: Demory Beckler, Michelle, Higginbotham, James N., Franklin, Jeffrey L., Ham, Amy-Joan, Halvey, Patrick J., Imasuen, Imade E., Whitwell, Corbin, Li, Ming, Liebler, Daniel C., Coffey, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567858/
https://ncbi.nlm.nih.gov/pubmed/23161513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.022806
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