KRAS-dependent sorting of miRNA to exosomes

Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. To test whether exosomal RNAs also contribute to changes in gene expression in recipient cells, and whether mutant KRAS might regulate the composition of secreted microRNAs (miRNAs), w...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Cha, Diana J, Franklin, Jeffrey L, Dou, Yongchao, Liu, Qi, Higginbotham, James N, Demory Beckler, Michelle, Weaver, Alissa M, Vickers, Kasey, Prasad, Nirpesh, Levy, Shawn, Zhang, Bing, Coffey, Robert J, Patton, James G
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2015
Ämnen:
Human Biology and Medicine
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510696/
https://ncbi.nlm.nih.gov/pubmed/26132860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07197
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