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Telomeric G-quadruplexes are a substrate and site of localization for human telomerase
It has been hypothesized that G-quadruplexes can sequester the 3′ end of the telomere and prevent it from being extended by telomerase. Here we purify and characterize stable, conformationally homogenous human telomeric G-quadruplexes, and demonstrate that human telomerase is able to extend parallel...
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| Izdano u: | Nat Commun |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Pub. Group
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4510649/ https://ncbi.nlm.nih.gov/pubmed/26158869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8643 |
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