Fetal brain 11β-hydroxysteroid dehydrogenase type 2 selectively determines programming of adult depressive-like behaviors and cognitive function, but not anxiety behaviors in male mice

Stress or elevated glucocorticoids during sensitive windows of fetal development increase the risk of neuropsychiatric disorders in adult rodents and humans, a phenomenon known as glucocorticoid programming. 11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2), which catalyses rapid inactivation of gl...

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Détails bibliographiques
Publié dans:Psychoneuroendocrinology
Auteurs principaux: Wyrwoll, Caitlin, Keith, Marianne, Noble, June, Stevenson, Paula L., Bombail, Vincent, Crombie, Sandra, Evans, Louise C., Bailey, Matthew A., Wood, Emma, Seckl, Jonathan R., Holmes, Megan C.
Format: Artigo
Langue:Inglês
Publié: Pergamon Press 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510145/
https://ncbi.nlm.nih.gov/pubmed/26036451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psyneuen.2015.05.003
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