Dynamic changes in replication timing and gene expression during lineage specification of human pluripotent stem cells

Duplication of the genome in mammalian cells occurs in a defined temporal order referred to as its replication-timing (RT) program. RT changes dynamically during development, regulated in units of 400–800 kb referred to as replication domains (RDs). Changes in RT are generally coordinated with trans...

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Veröffentlicht in:Genome Res
Hauptverfasser: Rivera-Mulia, Juan Carlos, Buckley, Quinton, Sasaki, Takayo, Zimmerman, Jared, Didier, Ruth A., Nazor, Kristopher, Loring, Jeanne F., Lian, Zheng, Weissman, Sherman, Robins, Allan J., Schulz, Thomas C., Menendez, Laura, Kulik, Michael J., Dalton, Stephen, Gabr, Haitham, Kahveci, Tamer, Gilbert, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509994/
https://ncbi.nlm.nih.gov/pubmed/26055160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.187989.114
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