Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

Direct lineage reprogramming induces dramatic shifts in cellular identity, employing poorly understood mechanisms. Recently, we demonstrated that expression of Neurog2 or Ascl1 in postnatal mouse astrocytes generates glutamatergic or GABAergic neurons. Here, we take advantage of this model to study...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Masserdotti, Giacomo, Gillotin, Sébastien, Sutor, Bernd, Drechsel, Daniela, Irmler, Martin, Jørgensen, Helle F., Sass, Steffen, Theis, Fabian J., Beckers, Johannes, Berninger, Benedikt, Guillemot, François, Götz, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509553/
https://ncbi.nlm.nih.gov/pubmed/26119235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.05.014
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