Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

Direct lineage reprogramming induces dramatic shifts in cellular identity, employing poorly understood mechanisms. Recently, we demonstrated that expression of Neurog2 or Ascl1 in postnatal mouse astrocytes generates glutamatergic or GABAergic neurons. Here, we take advantage of this model to study...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Masserdotti, Giacomo, Gillotin, Sébastien, Sutor, Bernd, Drechsel, Daniela, Irmler, Martin, Jørgensen, Helle F., Sass, Steffen, Theis, Fabian J., Beckers, Johannes, Berninger, Benedikt, Guillemot, François, Götz, Magdalena
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509553/
https://ncbi.nlm.nih.gov/pubmed/26119235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.05.014
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