Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

Direct lineage reprogramming induces dramatic shifts in cellular identity, employing poorly understood mechanisms. Recently, we demonstrated that expression of Neurog2 or Ascl1 in postnatal mouse astrocytes generates glutamatergic or GABAergic neurons. Here, we take advantage of this model to study...

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Publicado en:Cell Stem Cell
Main Authors: Masserdotti, Giacomo, Gillotin, Sébastien, Sutor, Bernd, Drechsel, Daniela, Irmler, Martin, Jørgensen, Helle F., Sass, Steffen, Theis, Fabian J., Beckers, Johannes, Berninger, Benedikt, Guillemot, François, Götz, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509553/
https://ncbi.nlm.nih.gov/pubmed/26119235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.05.014
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