Загрузка...
Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human
The P2X7 receptor is a calcium permeable cationic channel activated by extracellular ATP, playing a role in chronic pain, osteoporosis and arthritis. A number of potential lead compounds are inactive against the rat isoform, despite good activity against the human homologue, making animal model stud...
Сохранить в:
| Опубликовано в: : | Bioorg Med Chem Lett |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Elsevier Science Ltd
2015
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4508345/ https://ncbi.nlm.nih.gov/pubmed/26099538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.001 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|