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Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability

Many correlated disease variables are analyzed jointly in genetic studies in the hope of increasing power to detect causal genetic variants. One approach involves assessing the relationship between each phenotype and each single nucleotide polymorphism (SNP) individually and using a Bonferroni corre...

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Publicat a:Hum Hered
Autors principals: Zhou, Jin J., Cho, Michael H., Lange, Christoph, Lutz, Sharon, Silverman, Edwin K., Laird, Nan M.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508328/
https://ncbi.nlm.nih.gov/pubmed/26111731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000381641
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