Improved Gene Targeting through Cell Cycle Synchronization

Gene targeting is a challenge in organisms where non-homologous end-joining is the predominant form of recombination. We show that cell division cycle synchronization can be applied to significantly increase the rate of homologous recombination during transformation. Using hydroxyurea-mediated cell...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Tsakraklides, Vasiliki, Brevnova, Elena, Stephanopoulos, Gregory, Shaw, A. Joe
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507847/
https://ncbi.nlm.nih.gov/pubmed/26192309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133434
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