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Robust synchronization of the cell cycle and the circadian clock through bidirectional coupling

The cell cycle and the circadian clock represent major cellular rhythms, which appear to be coupled. Thus the circadian factor BMAL1 controls the level of cell cycle proteins such as Cyclin E and WEE1, the latter of which inhibits the kinase CDK1 that governs the G2/M transition. In reverse the cell...

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Bibliografske podrobnosti
izdano v:J R Soc Interface
Main Authors: Yan, Jie, Goldbeter, Albert
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769306/
https://ncbi.nlm.nih.gov/pubmed/31506042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2019.0376
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