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FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP

Pre-mRNA splicing is coupled to transcription by RNA polymerase II (RNAP II). We previously showed that U1 small nuclear ribonucleoprotein (snRNP) associates with RNAP II, and both RNAP II and U1 snRNP are also the most abundant factors associated with the protein fused-in-sarcoma (FUS), which is mu...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yu, Yong, Reed, Robin
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507187/
https://ncbi.nlm.nih.gov/pubmed/26124092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506282112
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