A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

During angiogenesis, Rho-GTPases influence endothelial cell migration and cell–cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow. Here, using an organotypic system that recapitulates distinct stages of VEGF-dependent angiogenes...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Abraham, Sabu, Scarcia, Margherita, Bagshaw, Richard D., McMahon, Kathryn, Grant, Gary, Harvey, Tracey, Yeo, Maggie, Esteves, Filomena O.G., Thygesen, Helene H., Jones, Pamela F., Speirs, Valerie, Hanby, Andrew M., Selby, Peter J., Lorger, Mihaela, Dear, T. Neil, Pawson, Tony, Marshall, Christopher J., Mavria, Georgia
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507007/
https://ncbi.nlm.nih.gov/pubmed/26129894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8286
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