A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

During angiogenesis, Rho-GTPases influence endothelial cell migration and cell–cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow. Here, using an organotypic system that recapitulates distinct stages of VEGF-dependent angiogenes...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Abraham, Sabu, Scarcia, Margherita, Bagshaw, Richard D., McMahon, Kathryn, Grant, Gary, Harvey, Tracey, Yeo, Maggie, Esteves, Filomena O.G., Thygesen, Helene H., Jones, Pamela F., Speirs, Valerie, Hanby, Andrew M., Selby, Peter J., Lorger, Mihaela, Dear, T. Neil, Pawson, Tony, Marshall, Christopher J., Mavria, Georgia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507007/
https://ncbi.nlm.nih.gov/pubmed/26129894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8286
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