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Extended evaluation of a phase 1/2 trial on dosing, safety, immunogenicity, and overall survival after immunizations with an advanced-generation Ad5 [E1-, E2b-]-CEA(6D) vaccine in late-stage colorectal cancer

A phase 1/2 clinical trial evaluating dosing, safety, immunogenicity, and overall survival on metastatic colorectal cancer (mCRC) patients after immunotherapy with an advanced-generation Ad5 [E1-, E2b-]-CEA(6D) vaccine was performed. We report our extended observations on long-term overall survival...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Balint, Joseph P., Gabitzsch, Elizabeth S., Rice, Adrian, Latchman, Yvette, Xu, Younong, Messerschmidt, Gerald L., Chaudhry, Arvind, Morse, Michael A., Jones, Frank R.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506904/
https://ncbi.nlm.nih.gov/pubmed/25956394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-015-1706-4
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