Induction and Comparison of SIV immunity in Ad5 Naïve and Ad5 Immune Non-human Primates using an Ad5 [E1-, E2b-] based vaccine

The effectiveness of recombinant Adenovirus serotype 5 (Ad5) vectors to induce immune responses against targeted antigens has been limited by the presence of pre-existing or Ad5 vaccine induced anti-vector immunity. The Ad5 [E1-, E2b-] platform, a recombinant Ad5 with additional deletions, has been...

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Bibliographic Details
Main Authors: Gabitzsch, Elizabeth S, Xu, Younong, Balint, Joseph P, Balcaitis, Stephanie, Sanders-Beer, Brigitte, Jones, Frank R
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191297/
https://ncbi.nlm.nih.gov/pubmed/21864618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.08.038
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