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A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis mediated through FoxP3(+) CD8 T-cells

TNFα and IL-17 secreted by proinflammatory T-cells (T(EFF)) promote bone erosion by activating osteoclasts. We previously demonstrated that in addition to bone resorption, osteoclasts act as antigen presenting cells to induce FoxP3 in CD8 T-cells (Tc(REG)). The osteoclast-induced regulatory CD8 T-ce...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Buchwald, Zachary S., Yang, Chang, Nellore, Suman, Shashkova, Elena V., Davis, Jennifer L., Cline, Anna, Ko, Je, Novack, Deborah V., DiPaolo, Richard, Aurora, Rajeev
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506715/
https://ncbi.nlm.nih.gov/pubmed/25656537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2472
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