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Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones
Here we report the evolution of an orthogonal amber suppressor pyrrolysyl-tRNA synthetase (PylRS)/tRNA(CUA)(Pyl) pair that genetically encodes the post-translationally modified amino acid, ε-N-2-hydroxyisobutyryl-lysine (HibK), in bacteria and mammalian cells. HibK is a new type of histone mark that...
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| Udgivet i: | ACS Chem Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506705/ https://ncbi.nlm.nih.gov/pubmed/25909834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb501055h |
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