A potential small-molecule synthetic antilymphangiogenic agent norcantharidin inhibits tumor growth and lymphangiogenesis of human colonic adenocarcinomas through blocking VEGF-A,-C,-D/VEGFR-2,-3 “multi-points priming” mechanisms in vitro and in vivo

BACKGROUND: Tumor lymphangiogenesis plays an important role in promoting growth and metastasis of tumors, but no antilymphangiogenic agent is used clinically. Based on the effect of norcantharidin (NCTD) on lymphangiogenesis of human lymphatic endothelial cells (LECs), we firstly investigated the an...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Li, Xin-Ping, Jing, Wei, Sun, Jian-Jun, Liu, Zhong-Yan, Zhang, Jing-Tao, Sun, Wei, Zhu, Wei, Fan, Yue-Zu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506614/
https://ncbi.nlm.nih.gov/pubmed/26187792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1521-5
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