Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex**

In investigating the binding interactions between the human telomeric RNA (TERRA) G-quadruplex (GQ) and its ligands, it was found that the small molecule carboxypyridostatin (cPDS) and the GQ-selective antibody BG4 simultaneously bind the TERRA GQ. We previously showed that the overall binding affin...

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Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: Yangyuoru, Philip M, Di Antonio, Marco, Ghimire, Chiran, Biffi, Giulia, Balasubramanian, Shankar, Mao, Hanbin
Format: Artigo
Langue:Inglês
Publié: WILEY-VCH Verlag 2015
Sujets:
Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506565/
https://ncbi.nlm.nih.gov/pubmed/25421962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201408113
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