Small-Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases

The development of small molecules that inhibit protein–protein interactions continues to be a challenge in chemical biology and drug discovery. Herein we report the development of indole-based fragments that bind in a shallow surface pocket of a humanised surrogate of RAD51. RAD51 is an ATP-depende...

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Published in:ChemMedChem
Main Authors: Scott, Duncan E, Coyne, Anthony G, Venkitaraman, Ashok, Blundell, Tom L, Abell, Chris, Hyvönen, Marko
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506530/
https://ncbi.nlm.nih.gov/pubmed/25470112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402428
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