Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

Transverse and longitudinal relaxation times (T(1ρ) and T(1)) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS can be excited if the ligand compris...

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Détails bibliographiques
Publié dans:ChemMedChem
Auteurs principaux: Buratto, Roberto, Bornet, Aurélien, Milani, Jonas, Mammoli, Daniele, Vuichoud, Basile, Salvi, Nicola, Singh, Maninder, Laguerre, Aurélien, Passemard, Solène, Gerber-Lemaire, Sandrine, Jannin, Sami, Bodenhausen, Geoffrey
Format: Artigo
Langue:Inglês
Publié: WILEY-VCH Verlag 2014
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Full Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506523/
https://ncbi.nlm.nih.gov/pubmed/25196781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402214
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