Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

Transverse and longitudinal relaxation times (T(1ρ) and T(1)) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS can be excited if the ligand compris...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Buratto, Roberto, Bornet, Aurélien, Milani, Jonas, Mammoli, Daniele, Vuichoud, Basile, Salvi, Nicola, Singh, Maninder, Laguerre, Aurélien, Passemard, Solène, Gerber-Lemaire, Sandrine, Jannin, Sami, Bodenhausen, Geoffrey
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2014
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506523/
https://ncbi.nlm.nih.gov/pubmed/25196781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402214
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