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Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

Transverse and longitudinal relaxation times (T(1ρ) and T(1)) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS can be excited if the ligand compris...

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Detaylı Bibliyografya
Yayımlandı:ChemMedChem
Asıl Yazarlar: Buratto, Roberto, Bornet, Aurélien, Milani, Jonas, Mammoli, Daniele, Vuichoud, Basile, Salvi, Nicola, Singh, Maninder, Laguerre, Aurélien, Passemard, Solène, Gerber-Lemaire, Sandrine, Jannin, Sami, Bodenhausen, Geoffrey
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: WILEY-VCH Verlag 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506523/
https://ncbi.nlm.nih.gov/pubmed/25196781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402214
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