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Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

The development of in vitro molecular biomarkers to accurately predict toxicological effects has become a priority to advance testing strategies for human health risk assessment. The application of in vitro transcriptomic biomarkers promises increased throughput as well as a reduction in animal use....

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Vydáno v:Environ Mol Mutagen
Hlavní autoři: Li, Heng-Hong, Hyduke, Daniel R., Chen, Renxiang, Heard, Pamela, Yauk, Carole L., Aubrecht, Jiri, Fornace, Albert J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506269/
https://ncbi.nlm.nih.gov/pubmed/25733355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.21941
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