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Does It MEK a Difference? Understanding Immune Effects of Targeted Therapy
BRAF inhibitor treatment (BRAFi) enhances anti-tumor immunity, but is associated with increased intra-tumoral PD-L1 expression. MEK inhibitors (MEKi) may alter T-cell function, however recent studies demonstrate preserved T-cell infiltrate during treatment with BRAFi/MEKi. These data have important...
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| Udgivet i: | Clin Cancer Res |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506225/ https://ncbi.nlm.nih.gov/pubmed/26025561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0363 |
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