Measles Virus Defective Interfering RNAs Are Generated Frequently and Early in the Absence of C Protein and Can Be Destabilized by Adenosine Deaminase Acting on RNA-1-Like Hypermutations

Defective interfering RNAs (DI-RNAs) of the viral genome can form during infections of negative-strand RNA viruses and outgrow full-length viral genomes, thereby modulating the severity and duration of infection. Here we document the frequent de novo generation of copy-back DI-RNAs from independent...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Pfaller, Christian K., Mastorakos, George M., Matchett, William E., Ma, Xiao, Samuel, Charles E., Cattaneo, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505647/
https://ncbi.nlm.nih.gov/pubmed/25972541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01017-15
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