Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells

CRD-BP/IGF2BP1 has been characterized as an “oncofetal” RNA binding protein typically highly expressed in embryonic tissues, suppressed in normal adult tissues, but induced in many tumor types. In this study, we show that adult breast tissues express ubiquitous but low levels of CRD-BP protein and m...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Fakhraldeen, Saja A., Clark, Rod J., Roopra, Avtar, Chin, Emily N., Huang, Wei, Castorino, John, Wisinski, Kari B., Kim, TaeWon, Spiegelman, Vladimir S., Alexander, Caroline M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505587/
https://ncbi.nlm.nih.gov/pubmed/25861986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655175
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