Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells

CRD-BP/IGF2BP1 has been characterized as an “oncofetal” RNA binding protein typically highly expressed in embryonic tissues, suppressed in normal adult tissues, but induced in many tumor types. In this study, we show that adult breast tissues express ubiquitous but low levels of CRD-BP protein and m...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fakhraldeen, Saja A., Clark, Rod J., Roopra, Avtar, Chin, Emily N., Huang, Wei, Castorino, John, Wisinski, Kari B., Kim, TaeWon, Spiegelman, Vladimir S., Alexander, Caroline M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505587/
https://ncbi.nlm.nih.gov/pubmed/25861986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655175
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