The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency

The retinoblastoma (RB) tumor suppressor and related family of proteins play critical roles in development through their regulation of genes involved in cell fate. Multiple regulatory pathways impact RB function, including the ubiquitin-proteasome system with deregulated RB destruction frequently as...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Sengupta, Satyaki, Lingnurkar, Raj, Carey, Timothy S., Pomaville, Monica, Kar, Parimal, Feig, Michael, Wilson, Catherine A., Knott, Jason G., Arnosti, David N., Henry, R. William
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505513/
https://ncbi.nlm.nih.gov/pubmed/25903125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.599993
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